PMID: Pak J Pharm Sci. 2016 Jul ;29(4):1123-6. PMID: 27393447 Abstract Title: Radio sensitizing effect of aloe polysaccharide on pancreatic cancer bxpc-3 cells. Abstract: The roles of autophagy in pancreatic cancers are complex and may differ depending on tumor type or context. This study aimed to investigate if aloe polysaccharide can be used as a radio-sensitizing chemical to induce autophagy in pancreatic cancer cells. Pancreatic carcinoma BxPC-3 cells were divided into four groups: A control group, an aloe polysaccharide only group, a radiation only group and a radiation combined with aloe polysaccharide group (combination group). Transmission electron microscopy was used to observe ultra structural changes of autophagosomes in each cell group. The mRNA expressions of ULK1, GABARAPL1, BECN1, and BCL-2 were detected by real-time PCR. Autophagosomes or autophagolysosomes were observed in all experimental groups except the control group. Compared with the control group, ULK1 mRNA expression was up-regulated and BECN1 and BCL-2 mRNA expression were down-regulated in all groups (P
via Health News Spirulina http://www.greenmedinfo.com/article/aloe-polysaccharide-induces-autophagy-pancreatic-carcinoma-bxpc-3-cells-both-a
via Health News Spirulina http://www.greenmedinfo.com/article/aloe-polysaccharide-induces-autophagy-pancreatic-carcinoma-bxpc-3-cells-both-a