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Pomegranate demonstrated significant cardioprotection against daunorubicin-induced cardiotoxicity.7/30/2016
PMID: Int J Prev Med. 2016 ;7:85. Epub 2016 Jun 20. PMID: 27413516 Abstract Title: Potential Effects of Pomegranate on Lipid Peroxidation and Pro-inflammatory Changes in Daunorubicin-induced Cardiotoxicity in Rats. Abstract: BACKGROUND: Daunorubicin-induced acute cardiotoxicity caused by oxidative stress and free radical formation. Pomegranate possessed a significant in vitro free radical scavenging activity. Therefore, the aim of this study was estimations of the role of pomegranate effects in daunorubicin-induced cardiotoxicity.METHODS: A total of 21 Sprague male rats were allocated into three groups, seven animals in each group. Group A: Control group received distilled water. Group B: Treated group with daunorubicin 20 mg/kg via intraperitoneal injection daily for the 12(th) day for total cumulative dose of 240 mg/kg. Group C: Pretreatment group with pomegranate 25 mg/kg for 6 days orally, then daunorubicin 20 mg/kg administrated concomitantly for the next 6 days with a cumulative dose of 120 mg/kg. Cardiac troponin I([cTn I] pg/ml), malondialdehyde (MDA) (ng/ml), interleukin 17 (IL-17 pg/ml), and cardiac lactate dehydrogenase (LDH) (pm/ml), all these biomarkers were used to measure the severity of cardiotoxicity.RESULTS: Daunorubicin at a dose of 20 mg/kg lead to pronounced cardiac damage that reflected on through elevations of serum cTn and serum LDH levels significantly P
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PMID: Int J Vitam Nutr Res. 2016 Jul 14:1-7. Epub 2016 Jul 14. PMID: 27414418 Abstract Title: Effects of Pomegranate and Orange Juice on Antioxidant Status in Non-Alcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial. Abstract: AIM: The fruit of the pomegranate (Punica granatum) has a high content of polyphenols and is renowned for its antioxidant capabilities. In particular, it is recognized as reducing oxidative stress and, therefore, playing a productive role in obstructing the pathogenesis of fatty liver disease. The aim of the present study was to evaluate the effects of consumingpomegranate juice (high in antioxidant content) and orange juice (low in antioxidant content) when combined with a hypocaloric diet on liver enzymes and the antioxidant status of patients.METHODS: In a randomized clinical trial, 65 patients who exhibited non-alcoholic fatty liver disease (NAFLD) at a mean age of 39+/-8 years received 250 mL pomegranate juice or orange juice per day as a substitute for two servings of fruit in a hypocaloric diet over a period of 12 weeks. The subjects' levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total antioxidant capacity (TAC), malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) were measured at the beginning and end of the study.RESULTS: At the end of the study, the levels of liver enzymes and body mass index (BMI) had significantly decreased in both groups. A significant increase in TAC was also observed in the subjects in the pomegranate group (p
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PMID: BMC Complement Altern Med. 2016 ;16 Suppl 1:185. Epub 2016 Jul 18. PMID: 27454418 Abstract Title: In vitro and in vivoα-amylase and α-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.). Abstract: BACKGROUND: α-amylase and α-glucosidase digest the carbohydrates and increase the postprandial glucose level in diabetic patients. Inhibiting the activity of these two enzymes can control postprandial hyperglycemia, and reduce the risk of developing diabetes. Bitter gourd or balsam pear is one of the important medicinal plants used for controlling postprandial hyperglycemia in diabetes patients. However, there is limited information available on the presence of α-amylase and α-glucosidase inhibiting compounds. In the current study, the protein extracts from the fruits of M. charantia var. charantia (MCC) and M. charantia var. muricata (MCM) were tested for α-amylase and α-glucosidase inhibiting activities in vitro, and glucose lowering activity after oral administration in vivo.RESULTS: The protein extract from both MCC and MCM inhibited the activity ofα-amylase and α-glucosidase through competitive inhibition, which was on par with Acarbose as indicated by in vitro percentage of inhibition (66 to 69 %) and IC50 (0.26 to 0.29 mg/ml). Both the protein extracts significantly reduced peak blood glucose and area under the curve in Streptozotocin-induced diabetic rats, which were orally challenged with starch and sucrose.CONCLUSIONS: Protein extracts from the fruits of the two varieties of bitter gourd inhibitedα-amylase and α-glucosidase in vitro and lowered the blood glucose level in vivo on par with Acarbose when orally administrated to Streptozotocin-induced diabetic rats. Further studies on mechanism of action and methods of safe and biologically active delivery will help to develop an anti-diabeticoral protein drug from these plants.
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PMID: Semin Cancer Biol. 2016 Jul 21. Epub 2016 Jul 21. PMID: 27452666 Abstract Title: Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy. Abstract: Recently, there is a paradigm shift that the whole food-derived components are not 'idle bystanders' but actively participate in modulating aberrant metabolic and signaling pathways in both healthy and diseased individuals. One such whole food from Cucurbitaceae family is 'bitter melon' (Momordica charantia, also called bitter gourd, balsam apple, etc.), which has gained an enormous attention in recent years as an alternative medicine in developed countries. The increased focus on bitter melon consumption could in part be due to several recent pre-clinical efficacy studies demonstrating bitter melon potential to target obesity/type II diabetes-associated metabolic aberrations as well as its pre-clinical anti-cancer efficacy against various malignancies. The bioassay-guided fractionations have also classified the bitter melon chemical constituents based on their anti-diabetic or cytotoxic effects. Thus, by definition, these bitter melon constituents are at cross roads on the bioactivity parameters; they either have selective efficacy for correcting metabolic aberrations or targeting cancer cells, or have beneficial effects in both conditions. However, given the vast, though dispersed, literature reports on the bioactivity and beneficial attributes of bitter melon constituents, a comprehensive review on the bitter melon components and the overlapping beneficial attributes is lacking; our review attempts to fulfill these unmet needs. Importantly, the recent realization that there are common risk factors associated with obesity/type II diabetes-associated metabolic aberrations and cancer, this timely review focuses on the dual efficacy of bitter melon against the risk factors associated with both diseases that could potentially impact the course of malignancy to advanced stages. Furthermore, this review also addresses a significant gap in our knowledge regarding the bitter melon drug-drug interactions which can be predicted from the available reports on bitter melon effects on metabolism enzymes and drug transporters. This has important implications, given that a large proportion of individuals, taking bitter melon based supplements/phytochemical extracts/food based home-remedies, are also likely to be taking conventional therapeutic drugs at the same time. Accordingly, the comprehensively reviewed information here could be prudently translated to the clinical implications associated with any potential concerns regarding bitter melon consumption by cancer patients.
via Health News Spirulina http://www.greenmedinfo.com/article/reviews-dual-efficacy-bitter-melon-against-risk-factors-associated-obesitytmd- 4.5[home]Rolanda teaches you how to cook! Look out for ROLANDA & RICHARD!: http://bit.ly/29vNMcy New Wassabi episode every #WassabiWednesday! JOIN THE EVERYDAY JOURNEY Don’t forget to remember! mKay bYe! The post COOKING WITH ROLANDA! appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/sf/cooking-with-rolanda/ 4.5[home]Provided to YouTube by CDBaby Sweet Spirulina · Ayman Doorways ℗ 1995 Namya Publishing Released on: 1995-01-06 Auto-generated by YouTube. The post Sweet Spirulina appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/k/sweet-spirulina/ 5[home]The egg is one of the most widely consumed foods on the planet, so it’s about time we put together a list of nifty tricks involving eggs… Here is a list of topics we cover: -~-~~-~~~-~~-~- The post 14 Incredible Edible EGG Tricks! appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/sf/14-incredible-edible-egg-tricks/ 4.5[home]GardenFit The post Garden Fit appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/k/garden-fit/ 5[home]Visit: The post Superfoods & Elite Brain to Tissue Cell Connections Workshop appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/sf/superfoods-elite-brain-to-tissue-cell-connections-workshop/ 4[home]Subscribe for free to Dr. Greger’s videos at: DESCRIPTION: A new concept in biology tries to explain why the consumption of certain natural compounds in plants may mimic the lifespan-enhancing benefits of caloric restriction. If this subject interests you, make sure you see my last video, where I introduce the topic: Appropriating Plant Defenses (http://nutritionfacts.org/video/appropriating-plant-defenses). I previously introduced the concept of hormesis in my videos Enhanced Athletic Recovery Without Undermining Adaptation (http://nutritionfacts.org/video/enhanced-athletic-recovery-without-undermining-adaptation/) and Is Liquid Smoke Carcinogenic (http://nutritionfacts.org/video/is-liquid-smoke-flavoring-carcinogenic/ )? How else might we get the benefits of dietary restriction without starving ourselves? See: Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/xenohormesis-what-doesnt-kill-plants-may-make-us-stronger/ and he’ll try to answer it! http://www.NutritionFacts.org The post Xenohormesis – What Doesn’t Kill Plants May Make Us Stronger appeared first on Spirulina. via Health News Spirulina http://www.buyspirulinaalgae.com/k/xenohormesis-what-doesnt-kill-plants-may-make-us-stronger/ |
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