PMID: J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136 Abstract Title: Amelioration of acetaminophen induced hepatotoxicity by methanolic extract of pomegranate peels in rats. Abstract: OBJECTIVE: To observe the ameliorating effect by methanolic extract of pomegranate peel in acetaminophen-induced hepatotoxicity.METHODS: The randomised controlled study was conducted from July 2013 to June 2014 at the University of Health Sciences, Lahore, Pakistan, and comprised rats that were randomly divided into three equal groups. Control group A was given normal saline (5ml/kg), whereas group B and C were given 750mg/kg acetaminophen intraperitoneally dissolved in normal saline (5ml/kg) on 1st day of experiment. From Day 2 till day 14, group A and B were given distilled water (5ml/kg), while group C was given 50mg/kg methanolic extract of pomegranate peel dissolved in distilled water (5ml/kg) orally. On day 15, blood was collected through cardiac puncture, and livers were removed and processed for histological examination.RESULTS: There were 24 rats weighing 175±25gm each. Each group had 8(33.3%) rats. Mean liver aspartate aminotransferase at the end of the experiment in groups A, B and C were 97.88±19.45, 148.25±16.48 and 96.13±17.95U/L, while alanine transaminase levels were 51.50±15.38, 96.75±10.91 and 49.63±12.08 U/L (p
via Health News Spirulina http://www.greenmedinfo.com/article/methanolic-extract-pomegranate-peel-ameliorated-hepatic-damage-caused-acetamin
via Health News Spirulina http://www.greenmedinfo.com/article/methanolic-extract-pomegranate-peel-ameliorated-hepatic-damage-caused-acetamin