PMID: J Diet Suppl. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25688638 Abstract Title: Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. Abstract: ABSTRACT Oxidative stress is implicated in the pathogenesis of osteoarthritis. Curcuminoids are natural polyphenols with strong antioxidant capacity and may thus be helpful in the treatment of osteoarthritis. The present randomized double-blind placebo-controlled trial investigated the efficacy of curcuminoids in reducing systemic oxidative burden in patients suffering from knee osteoarthritis. Forty patients with mild-to-moderate primary knee osteoarthritis were given curcuminoid capsules (1500 mg/day in 3 divided doses; n = 19) or matched placebo capsules (n = 21) for a period of 6 weeks. Curcuminoids were co-administered with piperine (15 mg/day) in order to improve the bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of reduced glutathione (GSH) andmalonedialdehyde (MDA) were determined spectrophotometrically at baseline and at the end of the treatment period in both groups. Serum activities of SOD as well as GSH and MDA concentrations were comparable between the study groups at baseline (p>0.05). There was a significant elevation in serum SOD activities (mean change: 2.94± 3.73 vs. -0.38 ± 1.33; p
via Health News Spirulina http://www.greenmedinfo.com/article/short-term-supplementation-curcuminoids-attenuates-systemic-oxidative-stress
via Health News Spirulina http://www.greenmedinfo.com/article/short-term-supplementation-curcuminoids-attenuates-systemic-oxidative-stress