PMID: Eur Rev Med Pharmacol Sci. 2015 Sep ;19(17):3303-8. PMID: 26400538 Abstract Title: Resveratrol caused apoptosis in QGY-7701 cells. Abstract: OBJECTIVE: This study aims to evaluate the cytotoxicity of resveratrol in QGY-7701 cells using a cell viability assay and determine genetic damages after 24-h exposure to concentrations of 6, 12, and 24µmol·L-1.MATERIALS AND METHODS: Cell viability and genetic damages were determined using a WST-1 assay and Hoechst 33342 staining with single cell gel electrophoresis (SCGE), respectively. Reactive oxygen species (ROS) levels were also determined.RESULTS: The results demonstrated that resveratrol inhibited QGY-7701 cell growth and decreased their viability in a dose-dependent manner. Furthermore, resveratrol caused nuclear morphological changes and DNA damage, promoted ROS levels, and induced cell apoptosis.CONCLUSIONS: These results suggest that resveratrol may induce QGY-7701 cell apoptosis by triggering excessive ROS generation and DNA damage.
via Health News Spirulina http://www.greenmedinfo.com/article/resveratrol-may-induce-qgy-7701-cell-apoptosis-triggering-excessive-ros
via Health News Spirulina http://www.greenmedinfo.com/article/resveratrol-may-induce-qgy-7701-cell-apoptosis-triggering-excessive-ros