PMID: Food Funct. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26416794 Abstract Title: Evaluation of antioxidative and antitumor activities of extracted flavonoids from Pink Lady apples in human colon and breast cancer cell lines. Abstract: The antioxidative and anticancer effects of extracted flavonoids from Pink Lady apples on human colon cancer LoVo cells and breast cancer MCF-7 cells were evaluated. It was found that the antioxidative property of the peel-flavonoids (Peel-F) was more effective than that of the flesh-flavonoids (Flesh-F). Meanwhile, both the Peel-F and Flesh-F can inhibit cancer cell growth in a dose-dependent manner, with the IC50 values of 110.33± 2.52 mg mL(-1) and 378.14 ± 1.64 mg mL(-1) for LoVo cells and 58.42 ± 1.39 mg mL(-1) and 296.06 ± 3.71 mg mL(-1) for MCF-7 cells. This led to the conclusion that the Peel-F were more effective against cancer cells than the Flesh-F, and that the scavenging ROS effects were significantly higherin the Peel-F in vitro. Moreover, we also found that the generation of ROS is a critical mediator in apple flavonoid-induced cell apoptosis and the induction effect of the Peel-F was significantly higher than that of the Flesh-F.
via Health News Spirulina http://www.greenmedinfo.com/article/flavonoids-pink-lady-apples-can-inhibit-cancer-cell-growth-human-colon-cancer
via Health News Spirulina http://www.greenmedinfo.com/article/flavonoids-pink-lady-apples-can-inhibit-cancer-cell-growth-human-colon-cancer