PMID: Toxicol Mech Methods. 2015 May ;25(4):340-6. Epub 2015 May 21. PMID: 25996037 Abstract Title: Curcumin attenuates quinocetone-induced oxidative stress and genotoxicity in human hepatocyte L02 cells. Abstract: Quinocetone (QCT), a new quinoxaline 1,4-dioxides, has been used as antimicrobial feed additive in China. Potential genotoxicity of QCT was concerned as a public health problem. This study aimed to investigate the protective effect of curcumin on QCT-induced oxidative stress and genotoxicity in human hepatocyte L02 cells. Cell viability and intracellular reactive oxygen species (ROS), biomarkers of oxidative stress including superoxide dismutase (SOD) activity and glutathione (GSH) level were measured. Meanwhile, comet assay and micronucleus assay were carried out to evaluate genotoxicity. The results showed that, compared to the control group, QCT at the concentration ranges of 2-16 μg/mL significantly decreased L02 cell viability, which was significantly attenuated with curcumin pretreatment (2.5 and 5 μM). In addition, QCT significantly increased cell oxidative stress, characterized by increases of intracellular ROS level, while decreased endogenous antioxidant biomarkers GSH level and SOD activity (all p
via Health News Spirulina http://www.greenmedinfo.com/article/consumption-curcumin-may-be-plausible-way-prevent-quinoxaline-14-dioxides
via Health News Spirulina http://www.greenmedinfo.com/article/consumption-curcumin-may-be-plausible-way-prevent-quinoxaline-14-dioxides